abstract：BACKGROUND:Pleural fibrosis and malignant mesotheliomas (MM) occur after exposures to pathogenic fibers, yet the mechanisms initiating these diseases are unclear. RESULTS:We document priming and activation of the NLRP3 inflammasome in human mesothelial cells by asbestos and erionite that is causally related to release...

journal_title：Particle and fibre toxicology

authors： Hillegass JM,Miller JM,MacPherson MB,Westbom CM,Sayan M,Thompson JK,Macura SL,Perkins TN,Beuschel SL,Alexeeva V,Pass HI,Steele C,Mossman BT,Shukla A

更新日期：2013-08-13 00:00:00

abstract：BACKGROUND:Inhalation exposure studies of mice were conducted to determine if multi-walled carbon nanotubes (MWCNT) distribute to the tracheobronchial lymphatics, parietal pleura, respiratory musculature and/or extrapulmonary organs. Male C57BL/6 J mice were exposed in a whole-body inhalation system to a 5 mg/m3 MWCNT ...

journal_title：Particle and fibre toxicology

authors： Mercer RR,Scabilloni JF,Hubbs AF,Wang L,Battelli LA,McKinney W,Castranova V,Porter DW

更新日期：2013-08-09 00:00:00

abstract：BACKGROUND:Prior studies have demonstrated a rapid and progressive acute phase response to bolus aspiration of multi-walled carbon nanotubes (MWCNTs). In this study we sought to test the hypothesis that inhalation exposure to MWCNT produces a fibrotic response and that the response is chronically persistent. To address...

journal_title：Particle and fibre toxicology

authors： Mercer RR,Scabilloni JF,Hubbs AF,Battelli LA,McKinney W,Friend S,Wolfarth MG,Andrew M,Castranova V,Porter DW

更新日期：2013-07-30 00:00:00

abstract：BACKGROUND:Inhalative nanocarriers for local or systemic therapy are promising. Gold nanoparticles (AuNP) have been widely considered as candidate material. Knowledge about their interaction with the lungs is required, foremost their uptake by surface macrophages and epithelial cells. METHODS:Scnn1b-Tg and Wt mice inh...

journal_title：Particle and fibre toxicology

authors： Geiser M,Quaile O,Wenk A,Wigge C,Eigeldinger-Berthou S,Hirn S,Schäffler M,Schleh C,Möller W,Mall MA,Kreyling WG

更新日期：2013-05-16 00:00:00

abstract：BACKGROUND:Mitochondria are both a sensitive target and a primary source of oxidative stress, a key pathway of air particulate matter (PM)-associated diseases. Mitochondrial DNA copy number (MtDNAcn) is a marker of mitochondrial damage and malfunctioning. We evaluated whether ambient PM exposure affects MtDNAcn in a hi...

journal_title：Particle and fibre toxicology

authors： Hou L,Zhang X,Dioni L,Barretta F,Dou C,Zheng Y,Hoxha M,Bertazzi PA,Schwartz J,Wu S,Wang S,Baccarelli AA

更新日期：2013-04-29 00:00:00

abstract：BACKGROUND:Epidemiological evidence indicates that diabetic patients have increased susceptibility to adverse cardiovascular outcomes related to acute increases in exposures to particulate air pollution. However, mechanisms underlying these effects remain unclear. METHODS:To evaluate the possible mechanisms underlying...

journal_title：Particle and fibre toxicology

authors： Nemmar A,Subramaniyan D,Yasin J,Ali BH

更新日期：2013-04-15 00:00:00

abstract：:Titanium dioxide (TiO2) nanoparticles (NPs) are manufactured worldwide in large quantities for use in a wide range of applications. TiO2 NPs possess different physicochemical properties compared to their fine particle (FP) analogs, which might alter their bioactivity. Most of the literature cited here has focused on t...

journal_title：Particle and fibre toxicology

authors： Shi H,Magaye R,Castranova V,Zhao J

更新日期：2013-04-15 00:00:00

abstract：BACKGROUND:In myeloid cells the inflammasome plays a crucial role in innate immune defenses against pathogen- and danger-associated patterns such as crystalline silica. Respirable mineral particles impinge upon the lung epithelium causing irreversible damage, sustained inflammation and silicosis. In this study we inves...

journal_title：Particle and fibre toxicology

authors： Peeters PM,Perkins TN,Wouters EF,Mossman BT,Reynaert NL

更新日期：2013-02-12 00:00:00

abstract：BACKGROUND:Nanomaterials can be contaminated with endotoxin (lipopolysaccharides, LPS) during production or handling. In this study, we searched for a convenient in vitro method to evaluate endotoxin contamination in nanoparticle samples. We assessed the reliability of the commonly used limulus amebocyte lysate (LAL) a...

journal_title：Particle and fibre toxicology

authors： Smulders S,Kaiser JP,Zuin S,Van Landuyt KL,Golanski L,Vanoirbeek J,Wick P,Hoet PH

更新日期：2012-11-09 00:00:00

abstract：BACKGROUND:Particulate air pollution is associated with increased risk of cardiovascular disease and stroke. Although the precise mechanisms underlying this association are still unclear, the induction of systemic inflammation following particle inhalation represents a plausible mechanistic pathway. METHODS:We used ba...

journal_title：Particle and fibre toxicology

authors： Tsai DH,Amyai N,Marques-Vidal P,Wang JL,Riediker M,Mooser V,Paccaud F,Waeber G,Vollenweider P,Bochud M

更新日期：2012-07-06 00:00:00

abstract：:Particulate matter (PM) pollution is responsible for hundreds of thousands of deaths worldwide, the majority due to cardiovascular disease (CVD). While many potential pathophysiological mechanisms have been proposed, there is not yet a consensus as to which are most important in causing pollution-related morbidity/mor...

journal_title：Particle and fibre toxicology

authors： Grahame TJ,Schlesinger RB

更新日期：2012-06-19 00:00:00

abstract：BACKGROUND:Aluminum oxide-based nanowhiskers (AO nanowhiskers) have been used in manufacturing processes as catalyst supports, flame retardants, adsorbents, or in ceramic, metal and plastic composite materials. They are classified as high aspect ratio nanomaterials. Our aim was to assess in vivo toxicity of inhaled AO ...

journal_title：Particle and fibre toxicology

authors： Adamcakova-Dodd A,Stebounova LV,O'Shaughnessy PT,Kim JS,Grassian VH,Thorne PS

更新日期：2012-06-19 00:00:00

abstract：BACKGROUND:In nanotoxicology, the exact role of particle shape, in relation to the composition, on the capacity to induce toxicity is largely unknown. We investigated the toxic and immunotoxic effects of silver wires (length: 1.5 - 25 μm; diameter 100 - 160 nm), spherical silver nanoparticles (30 nm) and silver micropa...

journal_title：Particle and fibre toxicology

authors： Stoehr LC,Gonzalez E,Stampfl A,Casals E,Duschl A,Puntes V,Oostingh GJ

更新日期：2011-12-30 00:00:00

abstract：BACKGROUND:The alveolar macrophage (AM) - first line of innate immune defence against pathogens and environmental irritants - constitutively expresses peroxisome-proliferator activated receptor γ (PPARγ). PPARγ ligand-induced activation keeps the AM quiescent, and thereby contributes to combat invaders and resolve infl...

journal_title：Particle and fibre toxicology

authors： Götz AA,Vidal-Puig A,Rödel HG,de Angelis MH,Stoeger T

更新日期：2011-09-20 00:00:00

abstract：BACKGROUND:Exposure to particulate matter (PM) air pollution may be an important environmental factor leading to exacerbations of inflammatory illnesses in the GI tract. PM can gain access to the gastrointestinal (GI) tract via swallowing of air or secretions from the upper airways or mucociliary clearance of inhaled p...

journal_title：Particle and fibre toxicology

authors： Mutlu EA,Engen PA,Soberanes S,Urich D,Forsyth CB,Nigdelioglu R,Chiarella SE,Radigan KA,Gonzalez A,Jakate S,Keshavarzian A,Budinger GR,Mutlu GM

更新日期：2011-06-09 00:00:00

abstract：BACKGROUND:It has been suggested that carbon nanotubes might conform to the fibre pathogenicity paradigm that explains the toxicities of asbestos and other fibres on a continuum based on length, aspect ratio and biopersistence. Some types of carbon nanotubes satisfy the first two aspects of the fibre paradigm but only ...

journal_title：Particle and fibre toxicology

authors： Osmond-McLeod MJ,Poland CA,Murphy F,Waddington L,Morris H,Hawkins SC,Clark S,Aitken R,McCall MJ,Donaldson K

更新日期：2011-05-13 00:00:00

abstract：:There are certain concerns regarding the safety for the environment and human health from the use of engineered nanoparticles (ENPs) which leads to unintended exposures, as opposed to the use of ENPs for medical purposes. This review focuses on the unintended human exposure of ENPs. In particular, possible effects in ...

journal_title：Particle and fibre toxicology

authors： Simkó M,Mattsson MO

更新日期：2010-12-21 00:00:00

abstract：BACKGROUND:Surface charge and oxidative stress are often hypothesized to be important factors in cytotoxicity of nanoparticles. However, the role of these factors is not well understood. Hence, the aim of this study was to systematically investigate the role of surface charge, oxidative stress and possible involvement ...

journal_title：Particle and fibre toxicology

authors： Bhattacharjee S,de Haan LH,Evers NM,Jiang X,Marcelis AT,Zuilhof H,Rietjens IM,Alink GM

更新日期：2010-09-11 00:00:00

abstract：BACKGROUND:Biomass combustion contributes to the production of ambient particulate matter (PM) in rural environments as well as urban settings, but relatively little is known about the health effects of these emissions. The aim of this study was therefore to characterize airway responses in humans exposed to wood smoke...

journal_title：Particle and fibre toxicology

authors： Sehlstedt M,Dove R,Boman C,Pagels J,Swietlicki E,Löndahl J,Westerholm R,Bosson J,Barath S,Behndig AF,Pourazar J,Sandström T,Mudway IS,Blomberg A

更新日期：2010-08-20 00:00:00

abstract：BACKGROUND:The etiology and progression of neurodegenerative disorders depends on the interactions between a variety of factors including: aging, environmental exposures, and genetic susceptibility factors. Enhancement of proinflammatory events appears to be a common link in different neurological impairments, includin...

journal_title：Particle and fibre toxicology

authors： Gerlofs-Nijland ME,van Berlo D,Cassee FR,Schins RP,Wang K,Campbell A

更新日期：2010-05-17 00:00:00

abstract：:Particle biokinetics is important in hazard identification and characterization of inhaled particles. Such studies intend to convert external to internal exposure or biologically effective dose, and may help to set limits in that way. Here we focus on the biokinetics of inhaled nanometer sized particles in comparison ...

journal_title：Particle and fibre toxicology

authors： Geiser M,Kreyling WG

更新日期：2010-01-20 00:00:00

abstract：BACKGROUND:Nanometer silicon dioxide (nano-SiO2) has a wide variety of applications in material sciences, engineering and medicine; however, the potential cell biological and proteomic effects of nano-SiO2 exposure and the toxic mechanisms remain far from clear. RESULTS:Here, we evaluated the effects of amorphous nano...

journal_title：Particle and fibre toxicology

authors： Yang X,Liu J,He H,Zhou L,Gong C,Wang X,Yang L,Yuan J,Huang H,He L,Zhang B,Zhuang Z

更新日期：2010-01-19 00:00:00

abstract：: Air Pollution has been associated with significant adverse health effects leading to increased morbidity and mortality. Cumulative epidemiological and experimental data have shown that exposure to air pollutants lead to increased cardiovascular ischemic events and enhanced atherosclerosis. It appears that these assoc...

journal_title：Particle and fibre toxicology

authors： Araujo JA,Nel AE

更新日期：2009-09-18 00:00:00

abstract：BACKGROUND:Epidemiologic and animal studies have shown that particulate air pollution is associated with increased risk of lung and cardiovascular diseases. Although the exact mechanisms by which particles induce cardiovascular diseases are not known, studies suggest involvement of systemic acute phase responses, inclu...

journal_title：Particle and fibre toxicology

authors： Saber AT,Halappanavar S,Folkmann JK,Bornholdt J,Boisen AM,Møller P,Williams A,Yauk C,Vogel U,Loft S,Wallin H

更新日期：2009-04-20 00:00:00

abstract：BACKGROUND:Combustion generated particulate matter is deposited in the respiratory tract and pose a hazard to the lungs through their potential to cause oxidative stress and inflammation. We have previously shown that combustion of fuels and chlorinated hydrocarbons produce semiquinone-type radicals that are stabilized...

journal_title：Particle and fibre toxicology

authors： Balakrishna S,Lomnicki S,McAvey KM,Cole RB,Dellinger B,Cormier SA

更新日期：2009-04-17 00:00:00

abstract：INTRODUCTION:Exposure to air pollution is associated with increased cardiovascular morbidity, although the underlying mechanisms are unclear. Vascular dysfunction reduces arterial compliance and increases central arterial pressure and left ventricular after-load. We determined the effect of diesel exhaust exposure on a...

journal_title：Particle and fibre toxicology

authors： Lundbäck M,Mills NL,Lucking A,Barath S,Donaldson K,Newby DE,Sandström T,Blomberg A

更新日期：2009-03-13 00:00:00

abstract：BACKGROUND:Exposure to small size particulate matter in urban air is regarded as a risk factor for cardiovascular effects, whereas there is little information about the impact on the cardiovascular system by exposure to pure carbonaceous materials in the nano-size range. C60 fullerenes are nano-sized particles that are...

journal_title：Particle and fibre toxicology

authors： Vesterdal LK,Folkmann JK,Jacobsen NR,Sheykhzade M,Wallin H,Loft S,Møller P

更新日期：2009-02-25 00:00:00

abstract：BACKGROUND:Exposure to particulate matter is a risk factor for cardiopulmonary disease but the underlying molecular mechanisms remain poorly understood. In the present study we sought to investigate the cardiopulmonary responses on spontaneously hypertensive rats (SHRs) following inhalation of UfCPs (24 h, 172 mug.m-3)...

journal_title：Particle and fibre toxicology

authors： Upadhyay S,Stoeger T,Harder V,Thomas RF,Schladweiler MC,Semmler-Behnke M,Takenaka S,Karg E,Reitmeir P,Bader M,Stampfl A,Kodavanti UP,Schulz H

更新日期：2008-12-04 00:00:00

abstract：UNLABELLED:A novel methodology to detect unlabeled inorganic nanoparticles was experimentally demonstrated using a mixture of nano-sized (70 nm) and submicron (250 nm) silicon dioxide particles added to mammalian tissue. The size and concentration of environmentally relevant inorganic particles in a tissue sample can b...

journal_title：Particle and fibre toxicology

authors： Deering CE,Tadjiki S,Assemi S,Miller JD,Yost GS,Veranth JM

更新日期：2008-12-03 00:00:00

abstract：:This review considers the molecular toxicology of combustion-derived nanoparticles (CDNP) following inhalation exposure. CDNP originate from a number of sources and in this review we consider diesel soot, welding fume, carbon black and coal fly ash. A substantial literature demonstrates that these pose a hazard to the...

journal_title：Particle and fibre toxicology

authors： Donaldson K,Tran L,Jimenez LA,Duffin R,Newby DE,Mills N,MacNee W,Stone V

更新日期：2005-10-21 00:00:00